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Wednesday, March 26, 2008

Bronchitis

Bronchitis is an inflammation of the large bronchi (medium-size airways) in the lungs. It can lead to pneumonia.

Acute bronchitis
is usually caused by viruses or bacteria and may last several days or weeks. Acute bronchitis is characterized by cough and sputum (phlegm) production and symptoms related to the obstruction of the airways by the inflamed airways and the phlegm, such as shortness of breath and wheezing. Diagnosis is by clinical examination and sometimes microbiological examination of the phlegm. Treatment may be with antibiotics (if a bacterial infection is suspected), bronchodilators (to relieve breathlessness) and other treatments.

Chronic bronchitis is not necessarily caused by infection and is generally part of a syndrome called chronic obstructive pulmonary disease (COPD); it is defined clinically as a persistent cough that produces sputum (phlegm) and mucus, for at least three months in two consecutive years.

Causes:
bronchitis can be contagious. In about half of instances of acute bronchitis a bacterial or viral pathogen is identified. Typical viruses include respiratory syncytial virus, rhinovirus, influenza, and others.
Acute bronchitis can result from breathing irritating fumes, such as those of tobacco smoke or polluted air.

Symptoms:
Bronchitis may be indicated by an expectorating cough, shortness of breath (dyspnea) and wheezing. Occasionally chest pains, fever, and fatigue or malaise may also occur. Additionally, Bronchitis caused by Adenoviridae may cause systemic and gastrointestinal symptoms as well. However the coughs due to bronchitis can continue for up to three weeks or more even after all other symptoms have subsided.

Diagnosis:
A physical examination will often reveal decreased intensity of breath sounds, wheezing, rhonchi and prolonged expiration. Most doctors rely on the presence of a persistent dry or wet cough as evidence of bronchitis.

A variety of tests may be performed in patients presenting with cough and shortness of breath:

* A chest X-ray that reveals hyperinflation; collapse and consolidation of lung areas would support a diagnosis of pneumonia. Some conditions that predispose to bronchitis may be indicated by chest radiography.
* A sputum sample showing neutrophil granulocytes (inflammatory white blood cells) and culture showing that has pathogenic microorganisms such as Streptococcus species.
* A blood test would indicate inflammation (as indicated by a raised white blood cell count and elevated C-reactive protein).
* Neutrophils infiltrate the lung tissue, aided by damage to the airways caused by irritation.
* Damage caused by irritation of the airways leads to inflammation and leads to neutrophils being present.
* Mucosal hypersecretion is promoted by a substance released by neutrophils.
* Further obstruction to the airways is caused by more goblet cells in the small airways. This is typical of chronic bronchitis.

Treatment:
Antibiotics-In most cases, acute bronchitis is caused by viruses, not bacteria and it will go away on its own without antibiotics. To treat acute bronchitis that appears to be caused by a bacterial infection, or as a precaution, antibiotics may be given. However, a meta-analysis found that antibiotics may reduce symptoms by one-half day.

Smoking cessation-To help the bronchial tree heal faster and not make bronchitis worse, smokers should cut back on the number of cigarettes smoked daily or quit smoking completely to allow their lungs to recover from the layer of tar that often builds up over time.

Antihistamines-Using over-the-counter antihistamines may be harmful in the self-treatment of bronchitis. An effect of antihistamines is to thicken mucus secretions. Expelling infected mucus via coughing can be beneficial in recovering from bronchitis. Expulsion of the mucus may be hindered if it is thickened. Antihistamines can help bacteria to persist and multiply in the lungs by increasing its residence time in a warm, moist environment of thickened mucus.

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